INSPIRE: Improving Antibiotic Selection for Patients

What is INSPIRE?

The INSPIRE (INtelligent Stewardship Prompts to Improve Real-time Empiric Antibiotic Selection for Patients) bundle is a program for hospitals to reduce their use of unnecessary extended-spectrum (ES) antibiotics and increase patient safety.

The INSPIRE bundle is based on trials conducted with more than 200,000 patients admitted at over one hundred of hospitals across the nation. The intervention resulted in up to 35% reductions in days of therapy for ES antibiotic use.

What is the INSPIRE Empiric Antibiotic Stewardship Bundle?

The INSPIRE Empiric Antibiotic Stewardship Bundle includes three main components to support antibiotic stewardship efforts:

1. Precision medicine computerized physician order entry (CPOE) smart prompts that give patient-specific risk estimates for select infections due to a multidrug-resistant organism (MDRO) when extended-spectrum antibiotics are ordered and recommends standard-spectrum antibiotics in non-ICU patients with low (<10%) MDRO risk.
2. Provider feedback reports
3. Activities to support computerized physician order entry adoption (e.g., education and alignment of CPOE workflows)

Why adopt the INSPIRE Empiric Antibiotic Stewardship Bundle?

• 40% of all admitted patients receive unnecessary broad-spectrum antibiotics
• The INSPIRE Stewardship Bundle is specifically designed to reduce broad-spectrum antibiotic use
• The INSPIRE Stewardship Bundle has been clinically proven to safely reduce days of therapy in non-ICU patients

Stewardship Prompts to Improve Antibiotic Selection for Urinary Tract Infection

Stewardship Prompts to Improve Antibiotic Selection for Pneumonia

INSPIRE infection-specific documents

• Pneumonia (PNA)
• Urinary Tract Infections (UTI)
• Abdominal Infections (ABD)
• Skin & Soft Tissue Infections (SST)

INSPIRE implementation toolkits

• INSPIRE Bundle and Implementation
• Overview
• Antibiotic Stewardship Team toolkit
• Clinician toolkit
• IT toolkit