Official Title: A Phase Ib Open-Label, Multi-Center, Dose Escalation Trial of BI 764532 Given as Monotherapy Administered by Repeated Intravenous Infusions in Patients with Glioma Expressing DLL3
A Study On:
Brain and Nervous System
Study Description
A Phase Ib open-label, multi-center, dose escalation trial of
BI 764532 given as monotherapy administered by repeated
intravenous infusions in patients with glioma expressing DLL3
Eligibility
Eligibility Criteria
-Signed and dated written informed consent form (ICF1 and ICF2) in accordance with ICH-GCP and local legislation prior to admission to the trial
Tumours must be positive for DLL3 expression (defined as staining in >50% of tumour cells) by IHC on archived tumour tissue according to central pathology review
Adequate liver, bone marrow, and renal function
-Presence of extracranial metastatic or leptomeningeal disease
Previous treatment with therapies targeting DLL3
-Prior treatment with bevacizumab or other anti-VEGF or
anti-angiogenic treatment within 6 months prior to first
administration of BI 764532
Interested in Participating in this Trial?
Thank you for your interest with our team.
One of our specialists will be in contact with you soon.
Privacy Policy
University of California, Irvine - Study Information Sheet
UCI Center for Clinical Research Potential Participant Database
Lead Researcher
Maheswari Senthil, MD
UCI Center for Clinical Research
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