Official Title: Randomized Phase III Study of Mosunetuzumab vs. Rituximab for Low Tumor Burden Follicular Lymphoma
A Study On:
Non-Hodgkin's Lymphoma
Study Description
This phase III trial compares the effectiveness of rituximab to mosunetuzumab in treating patients with follicular lymphoma with a low tumor burden. Rituximab is a monoclonal antibody. It binds to a protein called CD20, which is found on B cells (a type of white blood cell) and some types of cancer cells. This may help the immune system kill cancer cells. Mosunetuzumab is a monoclonal antibody that may interfere with the ability of cancer cells to grow and spread. It is not yet known if giving rituximab or mosunetuzumab works better in treating patients with follicular lymphoma with a low tumor burden.
Eligibility
NOTE: This is NOT a comprehensive list of eligibility criteria. The list below describes key eligibility criteria for prospective study participants. A complete list of eligibility criteria will be available in the informed consent form.
Key inclusion criteria:
Participants must either be experiencing distress due to their disease or would prefer active management of their disease rather than a watch and wait approach
Participants must not have received allogeneic stem cell transplantation
Participants must not have a positive test result for COVID-19 within seven (7) days prior to registration
Participants must have a histologically confirmed diagnosis of classic follicular lymphoma (cFL). cFL was previously categorized as grade 1-3A per World Health Organization (WHO)-HAEM4R, but grading of classic follicular lymphoma (FL) is no longer mandatory.
Key exclusion criteria:
Participants who are pregnant or nursing (nursing includes breast milk fed to an infant by any means, including from the breast, milk expressed by hand, or pumped).
Interested in Participating in this Trial?
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Privacy Policy
University of California, Irvine - Study Information Sheet
UCI Center for Clinical Research Potential Participant Database
Lead Researcher
Maheswari Senthil, MD
UCI Center for Clinical Research
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